Table 2 Association of operational taxonomic units (OTUs) and clinical characteristics.

From: Gut microbiota composition in colorectal cancer patients is genetically regulated

OTU

V1-V2-V3 Dataseta

V4-V5-V6 Dataset

Clinical characteristic

Beta (P)b

Akkermansia

N

Y

None

–

Alistipes

Y

N

None

–

Bacteroides

Y

Y

None

–

Blautia

Y

Y

None

–

Collinsella

N

Y

Smoking

1.1 (0.045)2

Coprococcus

Y

Y

None

–

Dorea

Y

Y

Age at surgery

− 0.046 (0.023)2

Escherichia

Y

N

Age at surgery

0.079 (0.00074)1

Faecalibacterium

Y

Y

None

–

Gemmiger

N

Y

Tumor sitec

− 0.97 (0.033)2

Parabacteroides

Y

N

Smoking

0.89 (0.029)1

Prevotella

Y

N

None

–

Pseudomonas

Y

Y

Tumor sitec

0.93 (0.030)2

Robinsoniella

N

Y

None

–

Roseburia

Y

Y

Smoking

0.95 (0.035)1

Age at surgery

− 0.050 (0.0063)1

Age at surgery

− 0.045 (0.014)2

Ruminococcus

Y

Y

None

–

Stenotrophomonas

Y

N

None

–

  1. OTUs observed in > 25% of samples and with mean relative abundance > 1%, and associations between the clr-transformed relative abundance and patient characteristics, by multivariate linear regression.
  2. aSequence data from the six hypervariable regions were aggregated into two datasets (V1-V2-V3 and V4-V5-V6) and analyzed separately.
  3. bBeta and P-value from 1V1-V2-V3 or 2V4-V5-V6 datasets.
  4. cRectum/colon.
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