Table 2 GO (biological process) overrepresentation analysis of ME2 module in THP-1 macrophages co-cultured with MMNK-1 cholangiocytes.

From: Transcriptome analysis of human cholangiocytes exposed to carcinogenic 1,2-dichloropropane in the presence of macrophages in vitro

Gene set

Description

Size

Expected

Observed

Ratio

p-value

FDR

GO:1903047

Mitotic cell cycle process

788

8.70

33

3.79

3.2E−11

2.9E−07

GO:0007049

Cell cycle

1739

19.20

44

2.29

1.0E−07

1.3E−04

GO:0048285

Organelle fission

459

5.07

19

3.75

8.1E−07

6.1E−04

GO:0051338

Regulation of transferase activity

940

10.38

27

2.60

4.7E−06

2.7E−03

GO:0010324

Membrane invagination

60

0.66

6

9.06

5.1E−05

1.1E−02

GO:0051276

Chromosome organization

1143

12.62

27

2.14

1.4E−04

2.3E−02

GO:0009435

NAD biosynthetic process

53

0.59

5

8.54

2.9E−04

4.0E−02

  1. The table shows GO (biological process) overrepresentation analysis of ME2 module from the transcriptomic profiles of THP-1 macrophages co-cultured with MMNK-1 cholangiocytes when exposed to 1,2-DCP at 0, 0.1 or 0.4 mM for 24 h. The analysis was performed by WebGestalt with False Discovery Rate (FDR) cut-off value of 0.05.
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