Table 4 Genes whose expression changed dose-dependently following exposure to 1,2-DCP in MMNK-1 cholangiocytes co-cultured with THP-1 macrophages.
Genes | p-value | q-value | Mean ± SD of normalized values fold change | ||
|---|---|---|---|---|---|
1,2-DCP concentration | |||||
0 | 0.1 | 0.4 mM | |||
Upregulated | |||||
Aldehyde dehydrogenase 2 family (ALDH2) | 4.2E−05 | 4.5E−02 | 7.4 ± 2.3 1 | 7.5 ± 2.4 1.01 | 18.2 ± 2.3 2.27 |
Phosphodiesterase 7B(PDE7B) | 3.9E−05 | 4.4E−02 | 10.6 ± 1.7 1 | 15.7 ± 5.0 1.48 | 25.0 ± 1.7 2.36 |
DNA Ligase 1 (LIG1) | 1.6E−05 | 2.8E−02 | 157 ± 13 1 | 175 ± 15 1.12 | 213.0 ± 3.4 1.36 |
Fibronectin 1 (FN1) | 1.9E−05 | 2.9E−02 | 338.0 ± 5.3 1 | 375 ± 36 1.11 | 458 ± 24 1.35 |
General transcription factor IIE subunit 2 (GTF2E2) | 5.2E−05 | 4.9E−02 | 63.4 ± 7.3 1 | 67.1 ± 4.0 1.06 | 85.5 ± 4.4 1.35 |
Downregulated | |||||
Small nucleolar RNA, C/D box 32A (SNORD32A) | 1.1E−05 | 2.2E−02 | 6.2 ± 1.7 1 | 4.16 ± 0.78 0.68 | 0.31 ± 0.53 0.05 |
Histone cluster 3 H2B family member b (HIST3H2BB) | 5.6E−05 | 4.9E−02 | 4.7 ± 1.3 1 | 4.57 ± 0.75 0.98 | 0.69 ± 0.61 0.15 |
Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5) | 5.8E−05 | 4.9E−02 | 56.9 ± 4.2 1 | 55.8 ± 8.3 0.98 | 32.1 ± 4.0 0.57 |
Shugoshin 2 (SGO2) | 8.6E−06 | 1.9E−02 | 442 ± 19 1 | 415 ± 27 0.94 | 339 ± 12 0.77 |
Nucleic acid binding protein 2 (NABP2) | 3.6E−05 | 4.3E−02 | 486 ± 17 1 | 467.3 ± 5.6 0.96 | 434.0 ± 8.3 0.89 |
