Figure 4 | Scientific Reports

Figure 4

From: Human chorion-derived mesenchymal stem cells suppress JAK2/STAT3 signaling and induce apoptosis of cholangiocarcinoma cell lines

Figure 4

CH-CM regulates the expression of apoptosis-related proteins in CCA cell lines. (A) Increased expression of Bax, cleaved caspase-3 and cleaved PARP and decreased expression of Bcl-2 in CCA cells following culture in the presence of CH-CM at 50% and 75% compared with control (0%). (B) The relative protein level analysis showed significantly increased expression of Bax, cleaved caspase 3, and cleaved PARP and decreased expression of Bcl-2 in all CCA cell lines. All data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared to the control group. Full length western blots are provided in Supplementary Fig. 2.

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