Table 7 Reproducibility of hyperpolarized 13C pyruvate in aqueous solution as contrast agent for MRI.

From: Performance and reproducibility of 13C and 15N hyperpolarization using a cryogen-free DNP polarizer

No

c(13C) (mM)

TDNP (s)

ttrans (s)

\(S^{lsHP}\)(a.u)

\(S^{lsTP}\)/106 (a.u)

ε

P(ttrans) (%)

P(0) (%)

T1 (s)

pH

1

61.19

1000

19

46.2

450

400,206

34

42.3

88

8.40

2

59.51

1047

19

37.2

380

385,863

33

39.6

101

8.32

3

58.39

1018

20

41.1

380

421,095

36

44.8

89

8.90

4

59.23

1048

20

46.5

330

547,196

46

57.5

94

8.77

5

56.14

1045

17

39.5

310

502,997

43

51.9

87

8.65

M

58.89

1032

19

42.1

370

451,471

38

47.2

92

8.60

cv

3.1%

2.1%

6.4%

8.8%

13.1%

13.9%

15.0%

15.6%

6.3%

2.8%

  1. Mean and coefficient of variance (cv) for concentration of 1-13C-PA after the dissolution, fitted time constant of the hyperpolarization build-up (TDNP), transfer time \({t}^{trans}\) to 1 T NMR, liquid-state NMR signal of hyperpolarized sample SlsHP normalized to the largest signal (sample 4), liquid-state NMR signal in thermal equilibrium (\({S}^{lsTP}\)) normalized to the largest signal (sample 1), polarization at the time of measurement P(ttrans), estimated polarization directly after the dissolution P(0) and lifetime (T1) of hyperpolarization at 1 T (the enhancement was calculated using flip angle α = 5º, RG = 31, ns = 1 for hyperpolarized sample, and α = 20º, with a RG = 31, and ns = 3600 for the thermally polarized sample). Significant values are in [bold].
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