Figure 4 | Scientific Reports

Figure 4

From: Overcoming addition of phosphoethanolamine to lipid A mediated colistin resistance in Acinetobacter baumannii clinical isolates with colistin–sulbactam combination therapy

Figure 4

Colistin and sulbactam combination therapy is efficacious in mouse thigh models of infection. (a) Single-dose treatment at 1 h post infection of either colistin (20 mg kg−1, i.p. n = 10), sulbactam (120 mg kg−1, p.o. n = 10), untreated (n = 10), or the combination (n = 10) in a neutropenic mouse thigh infection model using representative colistin-resistant A. baumannii isolates (a) 1251 and (b) 1374. Colony-forming units (CFU) within thigh tissue were enumerated at 8 h post infection and compared to the untreated group. Horizontal lines represent geometric mean of the bacterial load for each treatment group. P values were determined using a two-sided, Mann–Whitney U-test.

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