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Figure 1

From: An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancer

Figure 1

TBC1D8 expression as an indicator of overall survival and progression-free interval determined by Least absolute shrinkage and selection operator (LASSO) and Cox regression analysis in the The Cancer Genome Atlas (TCGA) cohort. (A) In the LASSO-Cox model based on TCGA-Colon Adenocarcinoma (COAD), the minimum standard was adopted to obtain the value of the super parameter λ by tenfold cross-validation, where the optimal lambda resulted in 2 non-zero coefficients (n = 480). (B) Cross-validation for selecting tuning parameters. (C–F) Univariate (C,E) and multivariate (D,F) Cox regression analysis for overall survival (C,D) and progression free interval (E,F) of the relationship between TBC1D8 and TBC1D17 levels and clinicopathological parameters related to CRC prognosis in TCGA-COAD (n = 480). (G,H) Overall survival (OS) (G), Disease-specific survival (DSS) (H), and Progression-free interval (PFI) (I) based on median TBC1D8 levels in TCGA-COAD (n = 480).

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