Figure 4 | Scientific Reports

Figure 4

From: Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

Figure 4

Domains of regulatory chromatin (DORCs) are enriched in myeloid cells, indicating epigenetic control of cell fate. (A) Number of peak-to-gene linkages in cells from IgG− subjects is shown by a plot of rank sorted genes as a function of number of correlated peaks. Genes with > 10 linkages are defined as DORCs. Labeled genes are known to be regulated by a super-enhancer. (B) DORC gene activity for 1109 loci plotted for each cell type (right). Labeled DORC genes are known to be regulated by a super-enhancer (top). (C) Super-enhancer regulated DORC genes for nuclear receptor corepressor 2 (NCOR2, left) and prosaposin (PSAP, right). Peak-to-gene linkages in CD14+ monocytes and other myeloid cells are plotted with a correlation cutoff of 0.5.

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