Figure 1
From: Efficacy of auranofin as an inhibitor of desmoid progression
Screening for FDA-approved drugs. The S45F-mutated cells were cultured for 24 h in a 96 well culture plate of 5 × 103 cells/well in the presence of 10 μM 1200 FDA-approved compounds. The cell proliferation was measured using the MTS assay, and the absorbance (at 490 nm) was measured using a microplate reader. The number of drugs is plotted for each growth inhibition rate of desmoid cells. If the relative absorption is less than 1, the growth inhibition will be stronger. Auranofin was extracted as an effective and safe drug, which had a proliferation rate of 0.324.
