Figure 5 | Scientific Reports

Figure 5

From: Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins

Figure 5

Increase of phosphorylated α-synuclein and hyper phosphorylated tau proteins in the thalamus of CtsD-CKO mice. Immunohistochemical staining of phosphorylated α-synuclein on S129, (phos-α Syn) (A,B) and phosphatase-sensitive epitope on PHF tau (C,D) in thalami of CtsD-CKO (B,D) and control mice (A,C) at p25. Scale bar: 20 µm. The phosphorylated α-synuclein- and PHF tau-positive cells in the thalamus of CtsD-CKO mice and age-matched control littermates were quantified (**p < 0.03; n = 3 sections form separate mice; Over 120 cells per each section were quantified).

Back to article page