Table 2 The incident rate of cardiovascular disease in patients with T2DM.

Total

152,709

100.00

87,732

57.45

64,977

42.55

66.37

Patients with/without chronic hepatitis

< 0.001

No liver-related disease

125,473

82.16

71,983

57.37

53,490

42.63

66.50

–

Hepatitis B

10,174

6.66

6292

61.84

3882

38.16

58.33

< 0.001

Hepatitis C

5056

3.31

2675

52.91

2381

47.09

79.91

< 0.001

Fatty liver disease

12,006

7.86

6782

56.49

5224

43.51

66.76

0.788

Sex

< 0.001

Male

75,815

49.65

44,746

59.02

31,069

40.98

63.60

–

Female

76,894

50.35

42,986

55.90

33,908

44.10

69.13

< 0.001

Duration of DM (years)

< 0.001

≤ 1

23,150

15.16

15,860

68.51

7290

31.49

45.56

–

1–5

26,260

17.20

16,562

63.07

9698

36.93

53.96

< 0.001

5 − 10

22,014

14.42

12,729

57.82

9285

42.18

64.28

< 0.001

> 10

21,931

14.36

11,223

51.17

10,708

48.83

81.04

< 0.001

Not performed

59,354

38.87

31,358

52.83

27,996

47.17

77.19

< 0.001

Age (year)

< 0.001

20–39

7757

5.08

6097

78.60

1660

21.40

27.44

–

40–54

46,455

30.42

31,499

67.81

14,956

32.19

44.71

< 0.001

55–64

49,038

32.11

28,121

57.35

20,917

42.65

65.32

< 0.001

65–74

34,682

22.71

16,147

46.56

18,535

53.44

94.64

< 0.001

≥ 75

14,777

9.68

5868

39.71

8909

60.29

131.08

< 0.001

Mean ± SD

59.32 ± 11.67

57.10 ± 11.59

62.33 ± 11.10

Monthly salary (NTD)

< 0.001

≤ 17,280

34,388

22.52

18,548

53.94

15,840

46.06

75.96

–

17,281–22,800

58,322

38.19

32,782

56.21

25,540

43.79

69.33

< 0.001

22,801–36,300

28,527

18.68

17,250

60.47

11,277

39.53

58.97

< 0.001

36,301–45,800

15,812

10.35

9613

60.80

6199

39.20

58.49

< 0.001

≥ 45,801

15,660

10.25

9539

60.91

6121

39.09

58.38

< 0.001

CCI score

< 0.001

0

97,806

64.05

59,990

61.34

37,816

38.66

56.70

–

1

33,761

22.11

17,709

52.45

16,052

47.55

78.66

< 0.001

2

12,938

8.47

6231

48.16

6707

51.84

93.50

< 0.001

≥ 3

8204

5.37

3802

46.34

4402

53.66

121.50

< 0.001

DCSI score (mean ± SD)

0.61 ± 0.95

0.51 ± 0.84

0.75 ± 1.07

0

93,835

61.45

57,598

61.38

36,237

38.62

< 0.001

57.66

–

1

35,511

23.25

19,597

55.19

15,914

44.81

70.61

< 0.001

≥ 2

23,363

15.30

10,537

45.10

12,826

54.90

102.47

< 0.001

Hypertension

< 0.001

No

66,137

43.31

45,531

68.84

20,606

31.16

43.13

–

Yes

86,572

56.69

42,201

48.75

44,371

51.25

88.53

< 0.001

Gout

< 0.001

No

141,581

92.71

82,159

58.03

59,422

41.97

65.04

–

Yes

11,128

7.29

5573

50.08

5555

49.92

84.89

< 0.001

BMI (kg/m²)^c

< 0.001

BMI < 18.5

1159

0.76

766

66.09

393

33.91

54.21

0.060

18.5 ≤ BMI < 24

47,270

30.95

28,624

60.55

18,646

39.45

59.67

–

24 ≤ BMI < 27

24,825

16.26

14,263

57.45

10,562

42.55

65.07

< 0.001

BMI ≥ 27

42,984

28.15

23,631

54.98

19,353

45.02

70.02

< 0.001

Not performed

36,471

23.88

20,448

56.07

16,023

43.93

72.64

< 0.001

Smoking

< 0.001

Never

144,528

94.64

82,683

57.21

61,845

42.79

66.93

–

Had

8181

5.36

5049

61.72

3132

38.28

56.98

< 0.001

Alcohol use

< 0.001

Never

149,014

97.58

85,428

57.33

63,586

42.67

66.68

–

Had

3695

2.42

2304

62.35

1391

37.65

54.64

< 0.001

Hospital level

< 0.001

Medical center

29,057

19.03

18,717

64.41

10,340

35.59

51.97

–

Regional

54,780

35.87

32,178

58.74

22,602

41.26

63.44

< 0.001

District

25,893

16.96

14,271

55.12

11,622

44.88

72.42

< 0.001

Clinic

42,979

28.14

22,566

52.50

20,413

47.50

77.54

< 0.001

HbA1c (%)

1st time (mean ± SD)

7.92 ± 1.68

7.87 ± 1.65

7.98 ± 1.71

 < 7

48,911

32.03

28,944

59.18

19,967

40.82

< 0.001

63.17

–

 7–9

72,271

47.33

41,498

57.42

30,773

42.58

65.95

< 0.001

 > 9

31,527

20.65

17,290

54.84

14,237

45.16

72.54

< 0.001

Average of 1st year (mean ± SD)

7.71 ± 1.30

7.64 ± 1.25

7.80 ± 1.35

CV (× 100)^d

8.68

8.57

8.83

SD (× 100)

69.46

67.89

71.57

Adjusted CV (× 100)^d

7.97

7.87

8.11

 CV ≤ 4.28

38,221

25.03

23,101

60.44

15,120

39.56

< 0.001

59.04

–

 4.28 < CV ≤ 6.60

38,083

24.94

22,004

57.78

16,079

42.22

64.91

< 0.001

 6.60 < CV ≤ 10.12

38,256

25.05

21,486

56.16

16,770

43.84

69.24

< 0.001

 CV > 10.12

38,149

24.98

21,141

55.42

17,008

44.58

73.01

< 0.001

Fasting blood glucose (mg/dl)

1st time (mean ± SD)

151.03 ± 52.55

149.42 ± 50.47

153.20 ± 55.15

 < 80

3086

2.02

1673

54.21

1413

45.79

< 0.001

77.46

–

 80–130

56,544

37.03

33,144

58.62

23,400

41.38

64.19

< 0.001

 > 130

93,079

60.95

52,915

56.85

40,164

43.15

67.37

< 0.001

Average of 1st year (mean ± SD)

148.69 ± 38.26

147.17 ± 36.57

150.74 ± 40.34

CV (× 100)^d

19.55

18.84

20.51

SD (× 100)

3028.09

2885.59

3220.20

Adjusted CV (× 100)^d

17.78

17.14

18.65

 CV ≤ 9.91

39,533

25.89

24,349

61.59

15,184

38.41

< 0.001

57.16

–

 9.91 < CV ≤ 15.23

37,699

24.69

22,322

59.21

15,377

40.79

61.66

< 0.001

 15.23 < CV ≤ 22.95

37,739

24.71

21,259

56.33

16,480

43.67

68.56

< 0.001

 CV > 22.95

37,738

24.71

19,802

52.47

17,936

47.53

80.22

< 0.001

LDL-C (mg/dl) (mean ± SD)^c

109.32 ± 32.63

108.85 ± 31.93

109.94 ± 33.55

< 100

61,315

40.15

35,405

57.74

25,910

42.26

< 0.001

66.24

–

100–130

54,498

35.69

31,623

58.03

22,875

41.97

64.87

0.021

> 130

36,896

24.16

20,704

56.11

16,192

43.89

68.83

< 0.001

Creatinine (mg/dl) (mean ± SD)

1.00 ± 0.57

0.95 ± 0.48

1.07 ± 0.67

eGFR(ml/min/1.73 m²) ≥ 90

36,759

24.07

24,458

66.54

12,301

33.46

< 0.001

47.94

–

60 ≤ eGFR ≤ 89

77,939

51.04

46,281

59.38

31,658

40.62

61.36

< 0.001

45 ≤ eGFR ≤ 59

24,178

15.83

11,975

49.53

12,203

50.47

86.00

< 0.001

30 ≤ eGFR ≤ 44

9911

6.49

3846

38.81

6065

61.19

123.98

< 0.001

15 ≤ eGFR ≤ 29

3130

2.05

927

29.62

2203

70.38

174.18

< 0.001

eGFR < 15

792

0.52

245

30.93

547

69.07

186.07

< 0.001

SGPT(u/l) (mean ± SD)^c

31.43 ± 31.34

32.39 ± 31.78

30.15 ± 30.70

< 35

37,501

24.56

20,958

55.89

16,543

44.11

< 0.001

68.38

–

35 − 100

12,275

8.04

7337

59.77

4938

40.23

60.86

< 0.001

> 100

1,284

0.84

820

63.86

464

36.14

55.62

< 0.001

Not performed

101,649

66.56

58,617

57.67

43,032

42.33

66.45

0.002

Triglycerides (mg/dl) (mean ± SD)

152.34 ± 157.07

147.78 ± 150.26

158.50 ± 165.61

< 150

95,912

62.81

56,942

59.37

38,970

40.63

< 0.001

62.23

–

150–200

25,271

16.55

13,897

54.99

11,374

45.01

71.86

< 0.001

> 200

31,526

20.64

16,893

53.58

14,633

46.42

75.23

< 0.001

UACR (mg/dl)

< 0.001

< 30

99,672

65.27

60,398

60.60

39,274

39.40

58.83

–

30–300

27,809

18.21

14,645

52.66

13,164

47.34

77.14

< 0.001

> 300

8286

5.43

3492

42.14

4794

57.86

106.50

< 0.001

Not performed

16,942

11.09

9197

54.29

7745

45.71

80.93

< 0.001