Figure 1 | Scientific Reports

Figure 1

From: Immune modulation by molecularly targeted photothermal ablation in a mouse model of advanced hepatocellular carcinoma and cirrhosis

Figure 1

Characterization of syngeneic murine HCC tumor model with cirrhosis. (A, B) Trichrome staining of liver tissue following 12 weeks of oral gavage of carbon tetrachloride demonstrates periportal and bridging fibrosis, recapitulating the histologic findings in human cirrhosis. (C, D) Orthotopic tumor implantation (blue arrow) exhibits a high rate of engraftment as well as a diffuse, infiltrative phenotype, a pattern commonly seen in aggressive hepatocellular carcinoma in patients.

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