Figure 3 | Scientific Reports

Figure 3

From: Mouse oocytes carrying metacentric Robertsonian chromosomes have fewer crossover sites and higher aneuploidy rates than oocytes carrying acrocentric chromosomes alone

Figure 3

Initiation of chromosome synapsis in Rb5, RBF, and WT BALB/c oocytes at the early zygotene stage. (a) Rb5 oocyte with six short SYCP1 stretches (1–4 µm). C-telomeres, D-telomeres and interstitial regions are distinguished with IF-staining with anti-TRF1 and CREST antibodies. The merged image is followed by SYCP1, TRF1, and CREST staining alone. The circle with broken line indicates RbT-centromeres. (b) Percentages of short SYCP1 stretches at three chromosomal regions from the oocytes of three genotypes. The number of short stretches per oocyte is given on the X axis. The total number of examined oocytes is given on the top of each column. The results are combined as total at the right end. Four females were examined in each strain. *Significance in RBF oocytes compared to WT oocytes at P < 0.05 by χ2-test.

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