Figure 4 | Scientific Reports

Figure 4

From: Mouse oocytes carrying metacentric Robertsonian chromosomes have fewer crossover sites and higher aneuploidy rates than oocytes carrying acrocentric chromosomes alone

Figure 4

Crossover sites in Rb5, RBF, and WT BALB/c oocytes. (a) Crossover sites marked with MLH1 IF-staining in oocytes of each genotype. Arrowheads indicate RbT chromosomes. White circle with broken line indicates a chromosome lacking MLH1 foci in an RBF oocyte. (b) Histogram of the number of either acrocentric (blue) or metacentric (red) chromosome arms with 0–4 MLH1 foci in the oocytes of each genotype. (c) Percentage of either acrocentric or metacentric chromosome arms lacking MLH1 foci in each oocyte. The combined results are shown in the “All” column. The total number of examined chromosome arms is given on the top of each column. (d) Percentages of oocytes with at least one chromosome pair lacking MLH1 foci. The total number of examined oocytes and females (in parentheses) are given on the top of each column. *Significant difference at P < 0.05 by χ2-test.

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