Table 3 Neonatal characteristics by survival outcome.

From: Neonatal outcomes in women with preterm premature rupture of membranes at periviable gestational age

 

Group 1 (17–23 weeks)

p value

Group 2 (24–27 weeks)

p value

Survived to discharged N = 19

Death

N = 5

Survived to discharged N = 24

Death

N = 3

Maternal characteristics

GW at PPROM (median, week)

22 ± 1.2 (19–23)

21 ± 2.3 (17–22)

0.036

26 ± 1.2 (24–27)

24 ± 1.2 (24–26)

0.139

Latency period (median, day)

50 ± 27.9 (12–105)

40 ± 31.9 (16–85)

1

17 ± 15.6 (7–61)

24 ± 5.6 (17–28)

0.635

Neonatal outcomes

GA at delivery (week)

29 ± 3.3 (24–34)

26.8 ± 2.8 (23–30)

0.235

29.4 ± 2.5 (25–34)

28 ± 1.7 (27–30)

0.437

Gender (male)

10 (52.6)

4 (80)

0.358

17 (70.8)

3 (100)

0.545

Birth weight (g)

1330.6 ± 473.9 (520–2120)

1042.6 ± 434.5 (488–1560)

0.265

1393.2 ± 412 (730–2270)

983 ± 107.2 (880–1094)

0.101

Apgar 1

5.4 ± 2.5 (1–9)

4 ± 2.1 (1–7)

0.235

6.5 ± 2.7 (1–9)

4 ± 2.6 (2–7)

0.139

Apgar 5

7.5 ± 1.5 (4–10)

7.8 ± 0.8 (7–9)

0.731

8.6 ± 1.7 (4–10)

6 ± 2 (4–8)

0.036

SGA

1 (5.3)

1 (20)

0.380

2 (8.3)

1 (33.3)

0.308

Cases of intubation

10 (52.6)

5 (100)

0.118

7 (29.2)

3 (100)

0.041

NCPAP use

16 (84.2)

0

0.001

20 (83.3)

1 (33.3)

0.115

Surfactant treatment

12 (63.2)

5 (100)

0.272

8 (33.3)

2 (66.7)

0.535

PPHTN

5 (26.3)

3 (60)

0.289

1 (4.2)

2 (66.7)

0.025

NO

4 (21.1)

2 (40)

0.568

0

1 (33.3)

0.111

Blood products

9 (47.4)

4 (80)

0.327

10 (41.7)

1 (33.3)

1

Steroid treatment

4 (21.1)

0

1

2 (8.3)

1 (33.3)

0.308

Pneumothorax

1 (5.3)

1 (20)

0.380

1 (4.2)

2 (66.7)

0.025

BSI

2 (10.5)

2 (0.4)

0.179

4 (16.7)

2 (66.7)

0.115

CLABSI

0

2 (40)

0.036

1 (4.2)

2 (66.7)

0.025

Hemodynamically significant PDA

3 (15.8)

0

1

2 (8.3)

0

1

Major morbidities

BPD

10 (52.6)

0

0.053

6 (25)

1 (33.3)

1

IVH grade 3–4

2 (10.5)

2 (20)

0.179

0

1 (33.3)

0.111

NEC

1 (5.3)

0

1

0

0

1

ROP

1 (5.3)

0

1

2 (8.3)

0

1

Hearing impairment*

4 (21.1)

–

NA

2 (8.3)

–

NA

  1. Data are expressed as mean ± standard deviation, median ± standard deviation or n (%).
  2. GA gestational age, GW gestational week, SGA small for gestational age, NCPAP nasal continuous positive airway pressure, BDP bronchopulmonary dysplasia, IVH intraventricular hemorrhage, PPHN persistent pulmonary hypertension of the newborn, NO nitric oxide, NEC necrotizing enterocolitis, BSI blood stream infection, ROP Retinopathy of prematurity, CLABSI Central Line Associated Bloodstream Infections, PDA Patent ductus arteriosus, NA not assessed.
  3. *7 missing values in group 1 and 4 missing values in group 2.
  4. Significant values are in bold.
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