Figure 4
Construction and validation of the CNV model. (A) Circos plot shows genes with different copy number alterations between HCC and non-tumor samples. The blue dots represent genes with copy number loss, and the black dots represent genes with copy number gain. (B) LASSO coefficients of the five key CNV genes. (C) The evaluation of the CNV model via ROC curve and C-index in the TCGA training set. (D) Kaplan–Meier survival analysis of the different risk groups stratified with the CNV risk score in the TCGA training set. Patients with no copy number alteration of the five key CNV genes were attributed to the low-risk group and the others to the high-risk group. (E) The verification of the CNV model via the ROC curve and C-index in the TCGA test set. (F) The validation of the CVN model with Kaplan–Meier survival analysis in the TCGA test set. HCC hepatocellular carcinoma, TCGA The Genome Cancer Atlas; C-index, Harrell’s concordance index, ROC receiver operating characteristic, AUC area under the curve, LASSO Least absolute shrinkage and selection operator, CNV copy number variation.
