Figure 6
Construction and validation of the multi-omics model. (A) Nomogram of the multi-omics model for predicting 1-, 3-, and 5-year OS in the TCGA training set. (B) Calibration plot for 1-, 3-, and 5-year OS of the multi-omics model in the TCGA training set. (C) The evaluation of the multi-omics model via the ROC curve and C-index in the TCGA training set. (D) Kaplan–Meier survival analysis of the different risk groups stratified with the trisection of the total point of the proposed nomogram in the TCGA training set. (E,F) Decision curve analysis for the multi-omics model and the five single-omic models at 1- and 3-year points in the TCGA training set. (G) Comparison of the predictive power of different models with C-index and ROC analysis in the TCGA training set. (H) The verification of the multi-omics model via the ROC curve and C-index in the TCGA test set. (I) The validation of the multi-omics model with Kaplan–Meier survival analysis in the TCGA test set. TCGA The Genome Cancer Atlas; C-index, Harrell’s concordance index, ROC receiver operating characteristic, AUC area under the curve, DCA decision curve analysis, OS overall survival, CNV copy number variation, SNP single nucleotide polymorphism.
