Figure 3
Experimental design. Rats under general anesthesia are made anemic. The first-hit is a myocardial infarction rendering rats volume incompliant. Randomization to placebo, low or high-dose furosemide is performed and prior to transfusion half of the product is administered. Subsequently two RBC units (2.0 mL) are transfused followed by a subsequent dose and transfusion of the remaining two units (2.0 mL). Rats are monitored up to 1 h post-transfusion. PV-catheter pressure–volume catheter, Art.line arterial line, CVC central venous cannula, Circ.vol circulating volume, LAD left-anterior descending coronary artery.
