Figure 3 | Scientific Reports

Figure 3

From: Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice

Figure 3

Effect of water avoidance stress or stress plus treatment with mirabegron or solifenacin on cumulative carbachol concentrations measured as (A) change in pressure and (B) normalised to KCl response; and phasic response to 1 µM carbachol measured as (C) frequency and (D) amplitude of phasic contractions. Data represents mean ± SEM (n = 6) and was analysed using two-way ANOVA with Tukey multiple comparisons test (A,B) or Kruskal–Wallis test Dunn’s multiple comparisons test (C,D) (A: *p < 0.05 Stressed vs Unstressed; C: *p < 0.05, **p < 0.01 Stressed vs Unstressed; #p < 0.05 Stress + Solifenacin vs Stressed).

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