Figure 4

Responses of isolated whole bladders from unstressed, stressed, and mirabegron and solifenacin treated mice to electrical field stimulation measured as (A) change in intravesical pressure and (B) normalised to KCl response; and (C) cumulative concentrations of the beta-adrenoceptor agonist isoprenaline following carbachol pre-contraction (1 µM). Data represent mean ± SEM (n = 6) and was analysed using two-way ANOVA with Tukey multiple comparisons test (*p < 0.05, **p < 0.01 Unstressed vs Stressed).