Figure 5

Effect of water avoidance stress or stress and treatment with mirabegron or solifenacin on total release of (A,B) ATP and (C,D) ACh into the intraluminal fluid (from inside of the bladder lumen) and serosal fluid (from the bathing solution) following distension of isolated whole bladders to 20 mmHg. Data is presented as mean ± SEM (n = 6) and was analysed using one-way ANOVA with Tukey–Kramer multiple comparisons test (**p < 0.01 vs Unstressed; ##p < 0.01 vs Stressed).