Table 1 Isolated whole bladder responses to carbachol and isoprenaline in unstressed, stressed, stress + mirabegron and stress + solifenacin groups.

From: Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice

 

Unstressed

Stressed

Stress + Mirabegron

Stress + Solifenacin

Carbachol

pEC50

5.6 ± 0.03

5.4 ± 0.05

5.6 ± 0.12

5.4 ± 0.06

Maximal response

∆Pressure (mmHg)

44.9 ± 1.03

60.3 ± 2.18**

49.2 ± 3.98 #

56.5 ± 2.63*

Response (% KCl)

159 ± 7.16

168 ± 9.43

146 ± 11.6

155 ± 9.71

Isoprenaline

pEC50

6.7 ± 0.18

6.8 ± 0.13

6.9 ± 0.19

6.9 ± 0.10

Maximal response (% of pre-contraction)

91.7 ± 6.11

67.5 ± 3.30 **

62.5 ± 4.18***

73.1 ± 2.77*

  1. Data is presented as mean ± SEM (n = 6) analysed using one-way ANOVA with Tukey–Kramer multiple comparisons test (*p < 0.05, **p < 0.01, ***p < 0.001 vs Unstressed; # p < 0.05 vs Stressed).
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