Table 2 Univariate and multivariate analyses for overall survival of GC patients before PSM (N = 903).

From: D-dimer, a predictor of bad outcome in gastric cancer patients undergoing radical resection

Parameters

Univariate analysis

Multivariate analysis

HR

95% CI

P value

HR

95% CI

P value

Gender

1.181

0.918–1.519

0.196

   

Age

1.72

1.389–2.13

 < 0.001

1.918

1.436–2.561

 < 0.001

Tumor location

 Proximal stomach

1

 

 < 0.001

  

0.404

 Distal stomach

0.549

0.434–0.694

 < 0.001

  

0.252

 Full stomach

1.118

0.832–1.504

0.459

  

0.958

PT

1.131

0.913–1.401

0.259

   

PTA

0.714

0.552–0.925

0.011

  

0.782

PTR

1.095

0.871–1.378

0.436

   

INR

1.57

1.116–2.209

0.01

  

0.917

APTT

1.162

0.874–1.543

0.301

   

TT

0.733

0.587–0.915

0.006

  

0.235

FIB

1.729

1.388–2.153

 < 0.001

  

0.214

D-dimer

2.486

1.982–3.118

 < 0.001

1.633

1.178–2.264

0.003

FDP

1.838

1.241–2.724

0.002

  

0.969

Platelet

1.023

0.743–1.41

0.453

   

LNR

9.42

6.67–13.303

 < 0.001

4.707

2.886–7.677

 < 0.001

Tumor size

1.158

1.119–1.198

 < 0.001

1.085

1.032–1.141

0.002

Histology

 Differentiated

1

     

 Bndifferentiated

1.055

0.841–1.324

0.641

   

TNM stage

 I

1

 

 < 0.001

1

 

 < 0.001

 II

2.631

1.618–4.277

 < 0.001

4.063

1.897–8.705

0.001

 III

6.166

4.15–9.161

 < 0.001

9.296

4.669–18.51

 < 0.001

Chemotherapy1

2.163

1.689–2.769

 < 0.001

0.42

0.286–0.615

 < 0.001

  1. HR, hazard ratio; CI, confidence interval; PT, prothrombin time; PTA, prothrombin activity; PTR, prothrombin ratio; APTT, activated partial prothrombin time; INR, international normalized ratio; TT, thrombin time; FIB, fibrinogen; FDP, fibrin degradation products; TNM, Tumor-node-metastasis; LNR, Lymph node ratio. Coagulation parameters were divided into two groups according to the cutoff values in Supplementary Table 2. The references of parameters were female, age < 65 years, PT < 13.2, PTA < 102.6, PTR < 1, INR < 0.96, APTT < 38.9, TT < 16.5, FIB < 3.8, D-dimer < 1, FDP < 2.1 and Platelet < 300. LNR and tumor size is analyzed as a continuous variable in univariate and multivariate analyses. 1This refers to adjuvant chemotherapy, the reference was no chemotherapy; adjuvant chemotherapy appeared to be a risk factor in univariate analysis because cox regression analysis included patients with TNM stage I who did not receive adjuvant chemotherapy.