Figure 4 | Scientific Reports

Figure 4

From: Transgenic expression of IL-7 regulates CAR-T cell metabolism and enhances in vivo persistence against tumor cells

Figure 4

IL-7 enhances the persistence of CAR-T cells in vitro tumor re-challenges. (A) A schematic representative of re-challenge experiment to assess CAR-T cell persistence in vitro. (B) Plots with lines show the Raji cell number (top), CD3 + T cells (middle) and percentage of CD8 + T cells (bottom) in different days after T cells co-culture with Raji cells. (C) Dot plot shows the cytokine production from NT T cells, 28z-CAR-T cells, and 28z/IL-7-CAR-T cells after culturing with or without Raji cells. Dot size indicates the log10 transformed values of cytokine concentration. (D) PCA analysis of the cytokine profile of NT T cells, 28z-CAR-T cells, and 28z/IL-7-CAR-T cells.

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