Figure 5
IL-7 secreting CAR T cells are persistent in vivo and associated with superior survival. (A) A schematic representative of murine model. (B) Kaplan–Meier plots shows the probability of survival for four groups of mice shown in indicated color scheme. Statistical significance is represented by log-rank (Mantel-cox) test *p < 0.05, **p < 0.01. (C) Bar plots show the percentage of Raji cells and T cells (left) and CD4 + T cells (right) in peripheral blood and mouse organs (bone marrow and spleen) from three different treatment groups (NT T cells, 28z-CAR-T cells, and 28z/IL7-CAR-T cells) (Error bars indicate median ± SEM, **p < 0.01, ****p < 0.0001, n = 3, unpaired t test). (D) Heatmap shows the cytokine production levels in mouse serum from three different groups (Raji alone, Raji + 28z-CAR-T cells, and Raji + 28z/IL7-CAR-T cells).
