Figure 4
From: Cell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia
The survival-related 5hmC signature is associated with leukemia burden. (a) Boxplot of wp-scores in controls (n = 42) and patient samples at initial diagnosis (n = 11), with chemotherapy (n = 35), after receiving hematopoietic stem cell transplant not in complete remission (HSCT non-CR; n = 13) or HSCT in CR (HSCT CR; n = 11). Red dashed line represents a cutoff wp-score of 18.0 developed from training set. Center line represents median, bounds of box represent 25th and 75th percentiles, and whiskers are Tukey whiskers. (b) Plots of wp-scores in individual AML patients at initial diagnosis and after chemotherapy. Dx, days after initiation of chemotherapy. Black dashed line represents the cutoff wp-score.
