Table 1 Top 20 differentially expressed genes identified by NanoString analyses in PBMCs obtained the day-of-surgery (DOS) and at 24 h after surgery (POD1) from 5 patients undergoing total knee arthroplasty for knee osteoarthritis, with Log2 fold-change > 1.5 and p < 0.05.

From: Association of circulating gene expression signatures with stiffness following total knee arthroplasty for osteoarthritis: a pilot study

Gene name

Log2FC

Lower

Upper

p value

CXCL1

2.59

1.57

3.61

0.00109

S100A8

2.53

2.1

2.96

2.99E−06

SOCS3

2.45

1.59

3.32

0.000531

S100A9

2.34

1.99

2.69

1.07E−06

CXCR1

2.29

1.56

3.03

0.000288

TNFRSF10C

2.13

1.61

2.66

4.60E−05

EGR1

2.04

1.22

2.85

0.0012

CCR1

2.01

1.53

2.49

3.74E−05

CR1

1.89

1.55

2.22

4.01E−06

CD163

1.88

1.38

2.38

7.89E−05

CCR2

1.8

1.29

2.31

0.000123

BCL3

1.78

1.44

2.12

7.30E−06

IL1RN

1.69

1.31

2.07

2.38E−05

CXCR2

1.67

1.15

2.2

0.000252

CD14

1.65

1.23

2.08

5.88E−05

LILRB4

1.64

1.16

2.12

0.000163

IL1R2

1.64

1.08

2.19

0.000426

LILRA5

1.58

1.11

2.05

0.000164

PLAUR

1.55

0.963

2.13

0.000829

  1. Log2 FC = Log2 fold change (POD1-vs-DOS).
  2. Lower = Lower confidence limit (log2).
  3. Upper = Upper confidence limit (log2).