Figure 6
Analysis of the DEGs. (a) Pathway enrichment analysis of genes significantly upregulated in interzone as compared to phalange. Color of the dot presents p.adj; size of the dot marks the number of genes involved in the pathway. The red rectangle marks pathway shown as enriched in the analysis of interzone-specific CEs as well as DEGs. (b) Heatmap presenting the differences in expression level of genes involved in the pathway: regulation of transmembrane receptor protein serine/threonine kinase signaling. (c) Pathway enrichment analysis of phalange upregulated DEGs. The red rectangle highlights pathways identified as enriched in for phalange specific CEs as well as DEGs. Color and size of the dot are as described above. (d) Heatmap presenting the expression level between interzone and phalange for genes involved in the pathways: endochondral bone morphogenesis and chondrocyte differentiation, respectively.
