Figure 2
From: Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA
(A) Scheme methodology of the detection of BCR::ABL1 mutations by RNA-NestedNGS; (B) Correlation between the two replicates by RNA-NestedNGS; (C) Histogram of mutational frequency by RNA-NestedNGS method in failure/warning stages for CML patients and diagnosis/relapse ALL patients; (D) Results from EUTOS international control round for deep sequencing analysis of BCR::ABL1 mutations using RNA-NestedNGS approach showing the ability of the nested method to detect KD mutations. ALL acute lymphoblastic leukemia, CML chronic myeloid leukemia, KD kinase domain.
