Figure 4
CR and HFD-feeding have no effect BM tumour burden. (a) Body weight over time, (b) Serum paraprotein levels over time, (c) Serum paraprotein levels at tumour endpoint (9 weeks post tumour initiation), (d) %GFP+ in the BM, (e) BM human MYC expression, (f) Correlation between %GFP+ in BM and BM human MYC expression, (g) Correlation between body weight and %GFP+ in BM, (h) Correlation between serum paraprotein and %GFP+ in BM. Error bars SEM, (a–e) n = 11–12 mice/group, ordinary one-way ANOVA with Tukey’s multiple comparisons test, (f–h) Combined data (n = 34 mice) from n = 11–12 mice/group, dot colours corresponds to diet group, blue dots: CR, black dots: NCD, red dots: HFD, correlation analysis, ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
