Table 1 The effect of dietary regimens on trabecular and cortical bone micro-architecture.

From: Calorie restriction has no effect on bone marrow tumour burden in a Vk*MYC transplant model of multiple myeloma

Bone properties

CR

NCD

HFD

Proximal tibia

Trabecular bone

BV/TV (%)

4.42 ± 0.48

4.85 ± 0.45

4.65 ± 0.155

Tb.Th (mm)

0.0451 ± 0.00061

0.0451 ± 0.00063

0.0429 ± 0.00033*#

Tb.N (1/mm)

0.98 ± 0.11

1.08 ± 0.10

1.09 ± 0.04

Tb.Sp (mm)

0.68 ± 0.04

0.62 ± 0.02

0.69 ± 0.04

Cortical bone

Tt.Ar (mm2)

2.94 ± 0.092

2.92 ± 0.079

3.09 ± 0.088

Ct.Ar (mm2)

0.81 ± 0.025*

0.88 ± 0.013

0.87 ± 0.010

Ct.Ar/Tt.Ar (%)

27.44 ± 0.784*

30.14 ± 0.694

28.13 ± 0.554

Midshaft tibia

Cortical bone

Tt.Ar (mm2)

1.429 ± 0.04

1.484 ± 0.05

1.449 ± 0.03

Ct.Ar (mm2)

0.835 ± 0.02

0.880 ± 0.03

0.867 ± 0.01

Ct.Ar/Tt.Ar (%)

58.48 ± 0.40

59.34 ± 0.75

59.87 ± 0.54

  1. Data are expressed as mean ± SEM from n = 5 mice/group; ordinary one-way ANOVA with Tukey’s multiple comparisons test. BV/TV bone volume/total volume, Tb.Th trabecular thickness, Tb.N trabecular number, Tb.Sp trabecular separation, Tt.Ar total cross-sectional area inside the periosteal envelope, Ct.Ar cortical bone area, Ct.Ar/Tt.Ar cortical area fraction. *p < 0.05 versus NCD group. #p < 0.01 compared to CR group.
Back to article page