Figure 3
From: Functional human cell-based vascularised cardiac tissue model for biomedical research and testing
Transmission electron microscopy showed improved structural maturity of cardiomyocytes in cardiac tissue model compared to cardiomyocyte monoculture. Immature cardiomyocytes in (a) the cardiomyocyte monoculture and (b) the cardiac tissue model contain unorganized myofibrils on day 1. (c) Monocultured cardiomyocytes have developed organized sarcomeres by day 7. (d) Two adjacent cardiomyocytes with highly developed and aligned sarcomeres show intercalated discs (IC) and desmosome connections (circled and magnified) in the cardiac tissue model on day 6. Light blue indicates the line between two adjacent cardiomyocytes. ER = endoplasmic reticulum, M = mitochondria, L = lipid droplet. Scale bar 1 µm. The experiment was performed with one well from CM day 1, two parallel wells from CTM day 1, two parallel wells from CM day 7, and two parallel wells from CTM day 6.
