Figure 3

ADAR1 and CCNI editing is promoted by chemotherapy, radiation, and CRT in HT29 cells. (A) ADAR1 expression levels and (B) CCNI RNA editing ratios in HT29 CRC cells treated with 5FU, CPT-11, OX, or control. (C) ADAR1 expression levels and (D) CCNI RNA editing ratios in HT29 CRC cells irradiated with 8 Gy, 16 Gy, or control. (E) ADAR1 expression levels and (F) CCNI RNA editing ratios in HT29 CRC cells treated with 5FU, CPT-11, or OX with radiation at 8 Gy or 16 Gy, or with the control. Wilcoxon’s signed-rank test. *p < 0.05, **p < 0.01, ***p < 0.001.