Figure 4 | Scientific Reports

Figure 4

From: RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer

Figure 4

ADAR1 and CCNI editing is promoted by chemotherapy, radiation, and CRT in Caco2 cells. (A) ADAR1 expression levels and (B) CCNI RNA editing ratios in Caco2 CRC cells treated with 5FU, CPT-11, OX, or control. (C) ADAR1 expression levels and (D) CCNI RNA editing ratios in Caco2 CRC cells irradiated at 8 Gy, 16 Gy, or control. (E) ADAR1 expression levels and (F) CCNI RNA editing ratios in Caco2 CRC cells treated with 5FU, CPT-11, or OX at a dose of 8 Gy or 16 Gy, or with the control. Wilcoxon’s signed rank test. *p < 0.05, **p < 0.01, ***p < 0.001.

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