Figure 5 | Scientific Reports

Figure 5

From: RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer

Figure 5

CRT promotes global RNA editing in CRC cells. (A) A radar chart was used to visualize ADAR1 expression and RNA editing levels for multiple comparisons. The numbers represent ADAR1 expression and CCNI editing level, respectively, and are compared among the chemotherapy, radiotherapy, and chemoradiotherapy (OX + radiation) groups. CRT including OX upregulated ADAR1 expression and CCNI RNA editing levels compared with levels observed with monotherapies in either HT29 or Caco2 cells. (B) AZIN1, GLI1, and APOBEC3D RNA editing ratios in HT29 CRC cells treated with OX and radiation at 8 Gy or with the control. (C) AZIN1, GLI1, and APOBEC3D RNA editing ratios in Caco2 CRC cells treated with OX and radiation at 16 Gy or with the control. Wilcoxon’s signed rank test. *p < 0.05, **p < 0.01, ***p < 0.001.

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