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Figure 1

From: Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats

Figure 1

Effects of the D1-like receptor antagonist SCH 23390 on nicotine and food intake and locomotor activity in male and female rats. The effects of SCH 23390 on nicotine (A 15 min; B 24 h) and food intake (C 15 min; D 24 h) and locomotor activity (E 15 min; F 24 h) were investigated. Treatment with SCH 23390 decreased nicotine and food intake and locomotor activity 15 min, but not 24 h, later. Nicotine self-administration (males n = 7, females, n = 9), operant responding for food and small open field test (males n = 8, females, n = 8). Asterisks indicate a significant difference from rats of the same sex that received vehicle. *P < 0.05, **P < 0.01, ***P < 0.001. Data are expressed as means ± SEM.

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