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Figure 2

From: Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats

Figure 2

Effects of the D1-like receptor agonist A77636 on nicotine and food intake and locomotor activity in male and female rats. The effects of A77636 on nicotine (A 15 min; B 24 h; C 48 h) and food intake (D 15 min; E 24 h; F 48 h) and locomotor activity (G 15 min; H 24 h; I 48 h) were investigated. Treatment with A77636 decreased nicotine intake 15 min, 24 h, and 48 h later. A77636 decreased food intake at the 15 min and 24 h time point and locomotor activity at the 48 h time point. Nicotine self-administration (males n = 9, females, n = 9), operant responding for food and small open field test (males n = 8, females, n = 8). Asterisks indicate a significant difference from rats of the same sex that received vehicle. *P < 0.05, **P < 0.01. Data are expressed as means ± SEM.

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