Figure 3 | Scientific Reports

Figure 3

From: Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells

Figure 3

siRNA screening to kinases involved in GB cell synthetic lethality in combination with PP2A reactivation. (A) GARP scores of siRNA screen in T98G cells under NZ-8-061-treatment or PME-1 depletion (left axis). Kinases were ordered according to synergy scores of a siRNA (right axis). (B) Heat map representation of kinases involved in synthetic lethality in NZ-8-061-treated and PME-1-depleted T98G cells. Color bar indicates the synergy scores. (C) STRING interactive mapping of screen kinase hits onto PP2A network.

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