Table 3 Summary of studies reported in the literature utilizing laser technologies to fabricate and improve electrode performance in neural interfacing applications.

From: Femtosecond laser hierarchical surface restructuring for next generation neural interfacing electrodes and microelectrode arrays

Publication

Findings

Schuettler et al.75,128,136

Reported on the use of laser cutting and laser patterning for fabrication of platinum electrodes

Schuettler134

Reported on the use of laser surface melting with ~ 4.5 times increase in the surface area of their electrodes

Green et al. 85,137

Found that the surface achieved by melt processing, imparted from the relatively long pulse duration required for roughening, increased surface bound oxides of Pt, preventing the full electrode area from being utilized for charge transfer

Stover et al.138

Investigated the feasibility and the potential use of femtosecond lasers to create defined channels into a conventional cochlear implant electrode array to allow for fluid-based drug delivery

Dodds et al.28

Reported on the use of laser patterning to fabricate microelectrode arrays for a stimulating retinal prosthesis with improved surface area and electrochemical activity

Henle et al.73

Reported on the first long term in-vivo study of implanted micro-ECoG electrodes manufactured and roughened by laser technology

Green et al.137

Reported that the surface area of an electrode was increased by ~ 2.5 times using an Nd:YAG laser with nanosecond pulse widths to roughen the electrode surface; they also reported that the safe charge injection limit was increased by ~ 3.5 times

Green et al.90

Reported on fabrication of electrode arrays with various laser patterning and roughening techniques with improvements in electrochemical performance and lower impedance compared to untreated surfaces of equal dimensions

Zhang et al.139

Investigated performance of laser-patterned platinum electrodes, in particular laser interference patterning, for use in visual prosthesis systems