Figure 4
From: A lignan from Alnus japonica inhibits glioblastoma tumorspheres by suppression of FOXM1
Effects of DFS on transcriptional profile, as determined by RNA-sequencing. (A) Oncogenic and tumor suppressor transcription factors measured by single gene set enrichment analysis (ssGSEA). (B) Expression of target genes of FOXM1 evaluated by RNA-sequencing. (C) Expression of Wnt signaling genes and β-catenin/TCF complex related genes evaluated by RNA-sequencing. (D) Heat map showing levels of expression of stemness- and invasiveness-associated genes. (E) Set of genes downregulated after treatment with DFS for 72 h. (F) Heat map showing levels of expression of cell cycle-related genes.
