Table 1 The 14 hit compounds from a screen of the NIHCCLI&II libraries for angiogenesis inhibitors.

From: Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor

Rank

Compound

% of negative control mean

Standard deviation (%)

1

Droperidol

65

8

2

3-Trifluoromethylphenylpiperazine (TFMPP)

70

15

3

Mesoridazine

55

21

4

Memantine Hydrochloride

65

23

5

Betaxolol Hydrochloride

65

24

6

Metaproterenol

54

25

7

PD 81,723

53

31

8

Famotidine

61

33

9

Rutin

62

34

10

Lomifylline

70

42

11

CGS 12066B

56

44

12

Raclopride

57

44

13

Mercaptopurine

67

45

14

CGS 15,943

48

51

  1. The library was screened three times. Compounds were considered hits if they reduced the endothelial network by 30% or more on average when compared to the average of the negative control endothelial network. More value was given to consistency; therefore, the compounds were ranked according to the standard deviation between the three replicates.
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