Figure 4 | Scientific Reports

Figure 4

From: Peripheral N-methyl-d-aspartate receptor activation contributes to monosodium glutamate-induced headache but not nausea behaviours in rats

Figure 4

Systemic administration of APV, KYNA and Olcegepant did not induce motor function or balance deficits. Comparison of the effect of APV (50 mg/kg; i.p.), KYNA (10, 50, 100 mg/kg; i.p.), olcegepant (1 mg/kg; i.p.) and vehicle on motor coordination and balance in 3 male and 3 female rats. (a) Schematic diagram illustrating the accelerated rotarod protocol used to assess motor coordination and balance. (b) The bar charts show the lack of effect of systemic administration of APV, KYNA and olcegepant on the mean relative latency, distance travelled and speed (RPM). Data are mean ± SEM (n = 6). Symbols represent individual data points. *P < 0.05. Time Epoch = P1 (0–10 min), P2 (10–20 min) and P3 (20–30 min). (Created with personal license of BioRender).

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