Figure 6 | Scientific Reports

Figure 6

From: Peripheral N-methyl-d-aspartate receptor activation contributes to monosodium glutamate-induced headache but not nausea behaviours in rats

Figure 6

OND and MTC ameliorated MSG induced headache-like behaviours but not nocifensive or exploratory behaviours. The effects of MTC (3 mg/kg; i.p.), OND (0.5 mg/kg; i.p.) and vehicle in combination with MSG (1000 mg/kg; i.p.) on (a) Grimace scores (b) Head-flick frequency (c) Mechanical withdrawal threshold (OND vs Vehicle *P < 0.05) (d) Facial grooming (e) Head scratches and (f) Rearing in 6 male rats. Both MTC and OND reduced head flick frequency. MTC also had a late effect on MSG-induced suppression of rearing behaviour. However, neither MTC nor OND had a significant effect on nocifensive or grooming behaviours. Data are mean ± SEM (n = 6). *P < 0.05. Time Epoch = P1 (0–10 min), P2 (10–20 min), P3 (20–30 min), P4 (30–40 min), P5 (40–50 min) and P6 (50–60 min) post injection.

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