Figure 3

AT2 deficiency does not affect the blood pressure, neurological outcome and the lesion volume: AT2-deficient mice (AT2^−/y; 24 h: n = 12; 5 days: n = 6; blue) were compared to age-matched WT mice (AT2^+/y; 24 h: n = 12; 5 days: n = 6; white). The values are presented in mean ± SD; n.s. = not significant. (A) Peritraumatic systolic blood pressure: time point 0 represents the intraoperative measurement immediately after CCI under general anesthesia, and the following postoperative time points measurements were performed in awake animals. The values were within the physiological norms and did not differ between the AT2^−/y and AT2^+/y animals. (B) The mNSS after CCI was not significantly different between the AT2^−/y and AT2^+/y animals. (C), (D) Cerebral lesion volume (to rule out effects of edema, data are expressed as % contralateral hemisphere): primary lesion was assessed 15 min after TBI, without difference between AT2^+/y and AT2^−/y animals. C: The marked secondary increase of lesion volume 24 after TBI (1 day post-injury, 1dpi; p < 0.001) was not different in AT2^+/y mice compared to AT2^−/y mice. (D): Five days after TBI (5dpi), there was no difference in the lesion volumes between the AT2^+/y and AT2^−/y mice.