Figure 4
AT2 deficiency does not affect the neuroinflammation and neurotrophins: AT2-deficient mice (AT2−/y; n = 6; blue) were compared to age-matched WT mice (AT2+/y; n = 6; white) 5 days after TBI (5 dpi). Values are presented in mean ± SD; n.s. = not significant. (A) The number of Iba-1-immunolabelled activated microglia/macrophages 5 days after CCI in the perilesional region of interest (0.52 × 0.65 mm2) was not different between the AT2+/y and AT2−/y groups. (B), (C), (D) The perilesional gene expressions of the cytokines IL1β and IL6 and of the neurotrophin BDNF, determined by qPCR, were not different between the AT2+/y and AT2−/y mice 5 days after TBI (5 dpi).
