Table 7 ROC curve analysis of hs-TnI and QTc for the diagnosis of cardiotoxicity.

From: Cardiac safety analysis of anti-HER2-targeted therapy in early breast cancer

Variables

Cutoff value

Sensitivity

1-Specificity

AUC

95% CI

P value

Hs-TnI (pg/ml)

3.35

0.733

0.325

0.724

0.605–0.843

0.001

QTc (ms)

434.5

0.467

0.075

0.713

0.588–0.839

0.002

  1. The cutoff values are the parameter value corresponding to the maximum value obtained by subtracting sensitivity − (1-specificity), at this threshold, the value of the Yoden index is the highest, that means, the highest accuracy of disease diagnosis.
  2. CI confidence interval, ROC receiver–operator characteristic.
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