Table 4 Regression results for CAM-ICU-7.

	Imputed coma				Coma not imputed
	Without medications in the model		With medications in the model		Without medications in the model		With medications in the model
	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value
SICU^a	0.72 (0.26)	0.01	0.38 (0.23)	0.10	0.56 (0.26)	0.03	0.24 (0.24)	0.31
Age^a	− 0.001 (0.01)	0.94	0.02 (0.01)	0.01	0.003 (0.01)	0.74	0.02 (0.01)	0.02
Female	− 0.22 (0.22)	0.33	− 0.10 (0.19)	0.60	− 0.13 (0.22)	0.55	0.00 (0.20)	0.99
Black^a	0.77 (0.22)	0.001	0.77 (0.19)	< 0.001	0.54 (0.21)	0.01	0.60 (0.19)	0.002
APACHE	0.00 (0.01)	0.92	0.01 (0.01)	0.51	0.01 (0.01)	0.62	0.01 (0.01)	0.36
CCI	0.06 (0.04)	0.19	0.06 (0.04)	0.13	0.03 (0.04)	0.50	0.04 (0.04)	0.35
IQCODE	− 0.04 (0.30)	0.90	0.15 (0.26)	0.57	0.06 (0.29)	0.83	0.27 (0.27)	0.32
Lawton	− 0.10 (0.05)	0.07	− 0.09 (0.05)	0.07	− 0.08 (0.05)	0.15	− 0.07 (0.05)	0.13
Haloperidol eligible study	0.19 (0.23)	0.40	− 0.01 (0.20)	0.94	0.19 (0.22)	0.39	− 0.02 (0.21)	0.94
Usual care	0.02 (0.22)	0.94	− 0.01 (0.19)	0.96	− 0.14 (0.21)	0.52	− 0.14 (0.19)	0.47
Any quetiapine^a			0.46 (0.37)	0.21			0.91 (0.37)	0.01
Log daily lorazepam equivalents^a			0.56 (0.08)	< 0.001			0.39 (0.09)	< 0.001
Log daily MME^a			0.29 (0.06)	< 0.001			0.28 (0.06)	< 0.001
Any propofol			0.26 (0.21)	0.20			− 0.03 (0.21)	0.90
Any dexmedetomidine			0.70 (0.35)	0.05			0.57 (0.35)	0.10
Log haloperidol dose			0.13 (0.17)	0.45			0.11 (0.18)	0.54

This table presents the linear regression analysis for delirium severity taking into account ICU type as well as other variables including medications. Delirium severity was determined by the mean of the CAM-ICU-7 scores in the first 7 days after enrollment.
SE standard error, APACHE II acute physiology and chronic health evaluation is a score which measures severity of illness, IADL instrumental activities of daily living (Lawton), ADL activities of daily living (Katz), SICU surgical intensive care unit, MICU medical intensive care unit, CCI Charlson Comorbidity Index, IQCODE informant questionnaire on cognitive decline in the elderly, MME morphine milligram equivalent.
^aSignificant differences in regression analysis.

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