Figure 2

CDA activity and mRNA levels are significantly higher in serum samples from RT-treated BC patients than in those from untreated healthy donors. (a) Scatter plot representation of CDA activity in enzymatic units/mg of protein in matched healthy donors (in black) and RT-treated BC patients (in gray). (b) Scatter plot representation of relative levels of CDA mRNA in matched healthy donors (in black) and RT-treated BC patients (in gray). (c) Scatter plot representation of CDA activity in enzymatic units/mg of protein in healthy donors (in black) and BC patients treated with RT (with or without HT; triangle in gray), or treated with RT plus CT, (with or without HT; circle in gray) (one patient for whom we did not have CT treatment information was not included in this analysis). For each panel, medians are represented by black horizontal lines and are indicated above each distribution. n is the number of individuals. Distributions were compared in Kruskal–Wallis tests or in Wilcoxon matched-pairs signed-rank tests (see “Materials and methods” section). Values of p < 0.05 were considered statistically significant.