Figure 5 | Scientific Reports

Figure 5

From: Alpinumisoflavone ameliorates choroidal neovascularisation and fibrosis in age-related macular degeneration in in vitro and in vivo models

Figure 5

Inhibitory effects of alpinumisoflavone (AIF) on VEGFA and alpha smooth muscle actin (alpha-SMA) expression in the laser-induced choroidal neovascularisation (CNV) mouse model. Intravitreal injection of 25 mg/mL AIF was administered immediately after laser exposure. Equal amounts of protein from laser-exposed mice eye tissue lysates were analysed for expression of the indicated proteins. Protein expression in CNV of laser-exposed eyes of mice was measured a week after laser exposure by western blot analysis. Data were analysed using one-way ANOVA followed by the Holm-Šídák post-hoc t-test (*p < 0.05 and **p < 0.01 vs. non-laser exposed group, ##p < 0.01 vs. only Laser exposed group) and the results are expressed as mean ± S.E. (n = 4–5). Uncropped blot images are presented in supplementary information (Supplementary Fig. 3).

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