Table 4 Disease characteristics of 18 patients with systemic mastocytosis stratified according the virtual-non-calcium attenuation values.

From: Functional imaging with dual-energy computed tomography for supplementary non-invasive assessment of mast cell burden in systemic mastocytosis

Characteristics

(#1) Increased VNCa values in SSM/AdvSM (n = 8)

(#2) Normal VNCa values in SSM/AdvSM (n = 4)

(#3) Normal VNCa values in ISM/SSM/AdvSM (n = 10)

P (#1) vs. (#2)

P (#1) vs. (#3)

Hemoglobin, g/dL (mean ± SD)

11.6 ± 1.5

9.5 ± 2.7

11.7 ± 3.0

n.s.

n.s.

Platelets, × 109/L (mean ± SD)

158 ± 72

203 ± 150

254 ± 105

n.s.

0.036

Serum tryptase, µg/L (mean ± SD)

437 ± 200

143 ± 40

87 ± 68

0.008

0.003

Albumin, g/dL (mean ± SD)

38 ± 3.8

37.4 ± . 2.6

40.0 ± 4.5

n.s.

n.s.

Alkaline phosphatase, U/L (mean ± SD)

339 ± 370

121 ± 65

88 ± 48

n.s.

n.s.

Bilirubin, mg/dL (mean ± SD)

0.83 ± 0.5

0.58 ± 0.25

0.56 ± 0.31

n.s.

n.s.

Mast cell infiltration in BM, % (mean ± SD)

45 ± 20

25 ± 15

16 ± 12

n.s.

0.004

KIT D816V EAB in PB, % (mean ± SD)

25 ± 18

12 ± 20

10 ± 14

n.s.

n.s.

KIT D816V EAB in BM, % (mean ± SD)

26 ± 23

19 ± 16

13 ± 12

n.s.

n.s.

  1. All patients with increased VNCa values were diagnosed as SSM/AdvSM.
  2. AdvSM advanced systemic mastocytosis, BM bone marrow, ISM indolent systemic mastocytosis, n.s. not. Significant, PB peripheral blood, SD standard deviation, SSM smoldering systemic mastocytosis, VNCa virtual-non-calcium attenuation.
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